Which file type requires immediate action upon confirmation of a hit?

The file type that requires immediate action upon confirmation of a hit is the Missing Person File. When a hit is confirmed in this file, it indicates that a person who has been reported missing has been located, which necessitates swift and decisive action to ensure the safety and well-being of the individual involved. Prompt action is crucial in these situations, as they often involve time-sensitive factors related to the person's safety or health.

In contrast, other file types, such as the Criminal History File and the Controlled Substance File, may require further investigation or procedures, but they do not typically necessitate immediate action in the same way that a confirmed hit in the Missing Person File does. Criminal History Files may involve ongoing legal processes, whereas Controlled Substance Files might lead to enforcement actions that can unfold over time. Thus, the urgency and imperative for immediate response in the case of missing persons make the Missing Person File the correct answer.